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Home > News Archive > T Cell Protein Boosts Learning

T Cell Protein Boosts Learning


Learning defects had been reported in mice lacking T cells, but how these cells boosted brain power was unknown. A team led by Jonathan Kipnis (University of Virginia, Charlottesville) investigated the activity of these cells in mice trained to find their way through a water maze. Training the mice caused T cells to accumulate in the membrane that surrounds the brain. Once there, the cells produced a protein called interleukin-4 (IL-4), which reduced the abundance of inflammatory proteins known to hinder learning. Mice lacking IL-4 had a hard time navigating the maze, but their learning disability could be reversed by giving them IL-4-producing T cells.

 

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